米歇尔(梅丽莎·麦卡西 Melissa McCarthy 饰)从小就过着寄人篱下的生活,看尽了人间冷暖世态炎凉的她,性格变得自负而又乖僻。长大后,米歇尔凭借着不懈的努力终于坐上了老板的位置,但她对手下的员工十分苛刻,甚至连对待甲方也是一副高高在上的嘴脸。很快,米歇尔的玩世不恭便让她尝到了苦头,因为内幕交易,她被判处了八个月的监禁。
从监狱里出来后的米歇尔失去了一切,所有的朋友和合作伙伴都对她避之不及。在这个节骨眼上,曾经被米歇尔苛待过的助理克莱尔(克里斯汀·贝尔 Kristen Bell 饰)站了出来向她伸出了援手。就这样,无家可归的米歇尔成为了克莱尔的室友。
A young girl stays with her estranged grandparents in the city while she waits for the results of her audition for an international performance group. Her grandparents welcome her, delighted about the chance to get to know their granddaughter better. While staying at the house, the girl gets to know her uncle, who suffers from a mysterious long-term lung illness and is mainly confined to bed. She also observes her grandmother's weird religious rituals, some involving a swimming pool in the basement. When the girl's father finds out that she is staying with his parents, he persuades his sister to visit the house to get her out, ending with a terrible tragedy.